Neurological Sciences and Neurophysiology

ORIGINAL ARTICLE
Year
: 2022  |  Volume : 39  |  Issue : 2  |  Page : 92--97

Cognitive evidence on EEG-P300 in healthy individuals with high depression scores


Didem Oz1, Yağmur Özbek2, İlayda Kiyi2, Bilge Targitay Öztürk3, İbrahim Öztura5, Görsev G Yener4 
1 Global Brain Health Institute, University of California San Francisco; Department of Neurosciences, Institute of Health Sciences, Dokuz Eylul University, Department of Neurology, Faculty of Medicine, Dokuz Eylul University, Izmir, Turkey
2 Department of Neurosciences, Institute of Health Sciences, Dokuz Eylul University, Izmir, Turkey
3 Department of Psychiatry, Izmir Ceşme Alper Çizgenakat State Hospital, Izmir, Turkey
4 Department of Neurology, Faculty of Medicine, Izmir University of Economics, Izmir, Turkey

Correspondence Address:
Didem Oz
Dokuz Eylül University Hospital, The Second Institution is Global Brain Health Institute
Turkey

Background: Depression is common among elderly and middle-aged individuals and is a reason for decreased quality of life. Depression may lead to impairments in cognitive abilities. The P300 potential is one of the most used event-related potentials (ERPs) to evaluate cognition. This study investigated the P300 amplitude differences between individuals with depressive symptoms and nondepressed healthy elderly individuals. Materials and Methods: The current study included twenty individuals with high depression scores (high DS, age: 64.80 ± 7.22, 6 M/14 F) and twenty demographically matched participants with low depression scores (low DS, age: 64.20 ± 6.21, 7 M/13 F). The Geriatric Depression Scale (GDS) was used to evaluate whether participants have depressive symptoms. All of the participants were underwent a comprehensive neuropsychological battery. The ERPs were recorded with a visual classical oddball paradigm. The P300 amplitudes were measured in the 250–550 ms time window. Results: High DS group had lower P300 amplitudes than low DS individuals regardless of electrode location. Correlation analyses showed that there was a significant correlation between GDS scores and the P300 amplitudes recorded from the Fz electrode. Conclusion: The current study showed the reduced P300 amplitudes on individuals with high GDS scores. The P300 potential may be a useful tool to determine possible changes or impairments due to subthreshold depressive symptoms.


How to cite this article:
Oz D, Özbek Y, Kiyi &, Öztürk BT, Öztura &, Yener GG. Cognitive evidence on EEG-P300 in healthy individuals with high depression scores.Neurol Sci Neurophysiol 2022;39:92-97


How to cite this URL:
Oz D, Özbek Y, Kiyi &, Öztürk BT, Öztura &, Yener GG. Cognitive evidence on EEG-P300 in healthy individuals with high depression scores. Neurol Sci Neurophysiol [serial online] 2022 [cited 2022 Sep 27 ];39:92-97
Available from: http://www.nsnjournal.org/article.asp?issn=2636-865X;year=2022;volume=39;issue=2;spage=92;epage=97;aulast=Oz;type=0