Neurological Sciences and Neurophysiology

CASE REPORT AND REVIEW OF THE LITERATURE
Year
: 2021  |  Volume : 38  |  Issue : 3  |  Page : 194--198

Refractory temporal lobe epilepsy in patients with mosaic turner syndrome: two case reports and literature review


Doruk Arslan1, Eda Ütine2, Serap Saygı1 
1 Department of Neurology, School of Medicine, University of Hacettepe, Ankara, Turkey
2 Department of Pediatric Genetics, School of Medicine, University of Hacettepe, Ankara, Turkey

Correspondence Address:

Turner syndrome (TS) is one of the most common sex chromosome abnormalities in women, but there are only a few case reports of patients with TS who have epilepsy or seizures. Here, we report two additional cases with drug-resistant temporal lobe epilepsy (TLE) and TS mosaicism. Patient #1 is a 22-year-old female with drug-resistant TLE whose karyotype analysis showed that 84% of interphase cells had (45,X) genotype and brain magnetic resonance imaging (MRI) initially reported as normal showed developmental left temporal lobe encephalocele. She underwent left temporal lobectomy, and she is seizure free for 10-year postoperative follow-up period. Patient #2 is a 49-year-old female who has TLE with normal brain MRI. The karyotype analysis showed that 2/30 of metaphase cells had (45, X) genotype. In addition, 11 cases of epilepsy associated with TS were determined through PubMed. The clinical characteristics of all are reviewed.


How to cite this article:
Arslan D, Ütine E, Saygı S. Refractory temporal lobe epilepsy in patients with mosaic turner syndrome: two case reports and literature review.Neurol Sci Neurophysiol 2021;38:194-198


How to cite this URL:
Arslan D, Ütine E, Saygı S. Refractory temporal lobe epilepsy in patients with mosaic turner syndrome: two case reports and literature review. Neurol Sci Neurophysiol [serial online] 2021 [cited 2021 Dec 5 ];38:194-198
Available from: http://www.nsnjournal.org/article.asp?issn=2636-865X;year=2021;volume=38;issue=3;spage=194;epage=198;aulast=Arslan;type=0