Neurological Sciences and Neurophysiology

ORIGINAL ARTICLE
Year
: 2021  |  Volume : 38  |  Issue : 2  |  Page : 90--96

Normative Values of Transcranial Magnetic Stimulation-Evoked Parameters for Healthy Developing Children and Adolescents


Hasan Tekgul1, Ulas Saz2, Muzaffer Polat1, Nurdan Tekgul3, Timur Kose4 
1 Department of Pediatrics, Division of Child Neurology, Faculty of Medicine, Ege University, Izmir, Turkey
2 Department of Pediatrics, Faculty of Medicine, Ege University, Izmir, Turkey
3 Adolescents Health Center, Clinic of Family Medicine, Tepecik Training and Research Hospital, Izmir University of Health Sciences, Izmir, Turkey
4 Department of Biostatistics, Faculty of Medicine, Ege University, Izmir, Turkey

Correspondence Address:
Hasan Tekgul
Department of Pediatrics, Division of Child Neurology, Faculty of Medicine, Ege University, Izmir
Turkey

Context: Normative data-containing transcranial magnetic stimulation (TMS) evoked parameters are essential for correctly interpreting healthy development and assessing neuroplastic changes in certain neurologic disorders. Aims: The aim is to investigate corticospinal pathways by applying TMS to healthy developing children and adolescents. Settings and Design: In this cross-sectional study, we measured TMS evoked parameters associated with cortical and spinal stimulation obtained from the four extremities of 46 healthy children and adolescents (21 boys and 25 girls; mean ± standard deviation age: 6.4 ± 1.2 years; range: 3.0–20.5 years). Statistical Analysis: Spearman's correlation coefficients were calculated for each variable (weight and height) as a function of motor evoked potential (MEP) response latency and central motor conduction time (CMCT). Pearson's Chi-square test was used to determine the inter-variable correlations. Results: Latencies of MEPs were correlated with age (P < 0.001, r = 0.6948) and height (P < 0.006, r = 0.7994). Amplitudes of active-state MEPs were significantly higher than those of resting-state MEPs associated with the upper and lower extremities. The mean values for active-state MEP latencies were lower than those for resting-state MEPs. The CMCT and magnitudes of latency jumps were calculated using reliable MEP data for children and adolescents. Additionally, the unresponsiveness rates were significantly higher for children aged below 7 years. Conclusion: The TMS evoked parameters investigated in this study are necessary to accurately assess corticospinal pathway development in healthy children and adolescents.


How to cite this article:
Tekgul H, Saz U, Polat M, Tekgul N, Kose T. Normative Values of Transcranial Magnetic Stimulation-Evoked Parameters for Healthy Developing Children and Adolescents.Neurol Sci Neurophysiol 2021;38:90-96


How to cite this URL:
Tekgul H, Saz U, Polat M, Tekgul N, Kose T. Normative Values of Transcranial Magnetic Stimulation-Evoked Parameters for Healthy Developing Children and Adolescents. Neurol Sci Neurophysiol [serial online] 2021 [cited 2022 Aug 17 ];38:90-96
Available from: http://www.nsnjournal.org/article.asp?issn=2636-865X;year=2021;volume=38;issue=2;spage=90;epage=96;aulast=Tekgul;type=0