E-ISSN 2636-865X
Research Article
Is There An Association Between Migraine and Atopic Disorders? The Results of Multicenter Migraine Attack Study
1 Mersin University Schol of Medicine, Neurology, MERSİN, Türkiye  
2 Mersin University Schol of Medicine, Microbiology, MERSİN, Türkiye  
3 Akdeniz University School of Medicine, Neurology, ANTALYA, Türkiye  
4 Ankara Training Hospital, Neurology, ANKARA, Türkiye  
5 İstanbul University, Cerrahpasa School of Medicine, Neurology, İSTANBUL, Türkiye  
6 Bakırköy Training Hospital, IInd Neurology Dept, Neurology, İSTANBUL, Türkiye  
7 İstanbul University, Istanbul School of Medicine, Neurology, İSTANBUL, Türkiye  
8 Ege University School of Medicine, Neurology, İZMİR, Türkiye  
9 Dokuz Eylül University, Faculty of Medicine, Department of Neurology, İzmir, Turkey  
10 Dokuz Eylül University School of Medicine, Neurology, İZMİR, Türkiye  
11 Kırıkkale University School of Medicine, Neurology, KIRIKKALE, Türkiye  
Neurol Sci Neurophysiol 2008; 25: 136-147

Key Words: Migraine, tension type headache, cytokine, immunologic, pro-inflammatory, anti-inflammatory.
Abstract

We designed this multicenter study to evaluate the abnormalities related to the mast cell activation during attacks in a large group of migraineurs and to compare the findings both with episodic tension type headache (ETTH) and matched healthy control subjects. After the evaluation of diagnostic criteria, 213 subjects were included in this study after giving consent. Of all 146 subjects (67.8%) were migraineurs, 38 (19.4%) were ETTH patients and 29 others were healthy controls matched according to age and sex. Immunological screening showed significantly high ratios of IL-1β, IL-2, IL-6 and TNF-α in the migraine group compared to ETTH (16.6% vs 10.5%, 20.0% vs 5.3%, 13.8% vs 2.6% and 15.9% vs 5.3%, respectively) and to the healthy controls. Logistic regression analysis showed that only duration of headache has an important effect on having IL-2 abnormality (Exp-B: 0.322, 95% CI: 0.151-0.688, p=0.003) in patients with migraine. There was no important effect of clinical variables on serological abnormalitites or each other. In conclusion, our multicenter clinical and laboratory based study suggests that primary headache disorders (migraine and ETTH) are associated with atopic changes and they might share the inflammatory mechanism (pro-inflammatory as well as anti-inflammatory cytokine abnormalities) during headache attacks.

 

How to cite this article:
A. OZGE, C. ÖZTÜRK, B. DORA, L. İNAN, S. SAİP, M. ÖZTÜRK, E. N. VANLI, F. GÖKÇAY, V. ÖZTÜRK, A. K. ERDEMOĞLU, F. TAŞMERTEK, N. YILMAZ, G. ÖZER, A. SİVA, N. DEMİR, B. BAYKAN, A. GÜLER, T. POYRAZ, H. DÖNER, H. ŞİRİN: Is There An Association Between Migraine and Atopic Disorders? The Results of Multicenter Migraine Attack Study. J Neurol Sci [Turk] 2008;25:136-147

 

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