E-ISSN 2636-865X
Research Article
Heat Shock Protein 27 in Migraine Patients
1 İzmir Eğitim ve Araştırma Hastanesi, Nöroloji, İzmir, Türkiye  
2 İzmir Eğitim ve Araştırma Hastanesi, Biokimya , İzmir, Türkiye  
Neurol Sci Neurophysiol 2011; 28: 28-34

Key Words: Heat shock protein 27, migraine, stress proteins

Aim: The pathophysiological mechanism of migraine is still obscure. Heat shock proteins (Hsp) are stres induced proteins in order to protect cells from stress and apoptosis. As migraine attack may constitute a stressful condition we aimed to look for whether an alteration of Hsp levels of migraine patients during the attacks occur.


Material and methods: Twenty-five migraine patients between 20-60 yeras of age were selected randomly from our outpatient clinic. Twenty five healthy subjects with similar ages consisted the control group. Any of the subjects with malignancy, autoimmune disease, infection or fever were excluded from the study. Blood samples were collected during migraine attack and remisssion (at least 7 days of attack free period) in the patient group. Serum Hsp27 levels were examined with Calbiochem® Oncogene kit by using ELISA method.


Results: The mean Hsp27 levels were during the attacks 2,63pg/ml, 2,48pg/ml during the remission period and 2,66 ±5,33pg/ml in the control group. Hsp27 levels during attack period was high, but the difference was not statistically meaningful (p=0,80). However the increase of Hsp27 level increase were meaningfully correlated with the Headache Severity Scores (HSS) (p= 0,02).


Discussion: In our study, the positive relationship of HSS during headache points that each migraine attack constitute a stress. The reason of nonmeaningful difference of the levels during attack and remission may be related to the smallness of our group.

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