E-ISSN 2636-865X
Research Article
Interleukin-23 concentrations of NREM-AHI greater than REM-AHI versus REM-AHI greater than NREMAHI in obstructive sleep apnea syndrome
1 Department of Neurology, Muğla Sıtkı Koçman University, School of Medicine, Muğla, Turkey  
2 Clinic of Neurology, Sandıklı State Hospital, Afyonkarahisar, Turkey  
3 Department of Medical Biochemistry, University of Health Sciences Gülhane School of Medicine, Ankara, Turkey  
4 Department of Medical Biochemistry, Muğla Sıtkı Koçman University, School of Medicine Muğla, Turkey  
Neurol Sci Neurophysiol ; : -
DOI: 10.5152/NSN.2019.11888
Key Words: Inflammation, interleukin-23, non-rapid eye movement sleep, obstructive sleep apnea syndrome, rapid eye movement sleep
Abstract

Objectives: Although the presence of a systemic inflammatory response is known in obstructive sleep apnea syndrome (OSAS), there have not been adequate investigations on the association of such a response with the predominance of apneas either in rapid eye movement (REM) or in the non-REM (NREM) phase. In this study, we compared interleukin (IL)-23 concentrations, a marker of systemic inflammatory process, in individuals with sleep apnea syndrome, whose apneas where predominant in the REM or NREM phase.

 

Methods: Fifty-four patients aged over 18 years who were diagnosed as having OSAS based on polysomnography (PSG) were included in the study. The apnea-hypopnea index (AHI) was used to divide patients into groups of AHIREM>AHINREM and AHINREM>AHIREM. In the blood samples drawn from the patients, IL-23 concentrations were measured using enzyme-linked immunosorbent assay (ELISA).

 

Results: The study included patients with OSAS aged 28-65 years, of whom 29 were AHIREM>AHINREM and 25 were AHINREM>AHIREM. The AHIREM>AHINREM OSAS group had no sex-based variance (14 males, 15 females), but the AHINREM>AHIREM group was substantially composed of males (21 males, 4 females). The average AHI of the AHINREM>AHIREM group (43.34±21.40) was significantly higher than in the AHIREM>AHINREM group (26.79±17.32). IL-23 concentrations were higher in patients with AHIREM>AHINREM sleep apnea (225.38±77.29) compared patients with AHINREM>AHIREM sleep apnea (183.68±78.49).

 

Conclusion: In AHIREM>AHINREM sleep apnea, the systemic inflammatory response may be more dramatic. Taking the AHIREM value into consideration along with the average AHI value seems to be important for treatment modalities.

 

You may cite this article as: Ünal Y, Aslan Öztürk D, Sertoğlu E, Saruhan E, Yılmaz N, Kutlu G. Interleukin-23 concentrations of NREM-AHI Greater than REM-AHI Versus REM-AHI Greater than NREM-AHI in Obstructive Sleep Apnea Syndrome. Neurol Sci Neurophysiol 2019; DOI: 10.5152/NSN.2019.11888

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