Neurological Sciences and Neurophysiology
Research Article

Biomarkers of neuronal damage and inflammation in delirium

1.

Department of Neurology, Adnan Menderes University School of Medicine, Aydın, Turkey

2.

Department of Neurosurgery, Adnan Menderes University School of Medicine, Aydın, Turkey

3.

Department of Anesthesiology and Reanimation, Adnan Menderes University School of Medicine, Aydın, Turkey

4.

Department of Biochemistry, Adnan Menderes University School of Medicine, Aydın, Turkey

Neurol Sci Neurophysiol 2019; 36: 193-197
DOI: 10.5152/NSN.2019.11310
Read: 67 Downloads: 44 Published: 19 November 2019

Objective: Inflammatory response and neuronal damage seem to be a part of the pathogenesis of delirium, but the exact mechanism, especially in motor subtypes of delirium, remains unclear.

 

Methods: This study included 53 patients with delirium and 50 intensive care unit patients without delirium. Interleukin (IL)-6, Neuron-specific enolase (NSE), and S100 beta (S100B) blood levels were examined in both groups. Patients with delirium were also investigated according to the delirium motor subtypes.

 

Results: There was no difference between the delirium and control groups with regard to S100B and NSE. However, the IL-6 levels of patients with delirium were significantly higher than those of the controls [24.73 pg/mL (2.91-99.36) vs. 5.44 pg/mL (2.75-89.32), p<0.001]. In a comparison of the subgroups of delirium, no statistical significance was found except that the IL-6 levels of hypoactive patients were delirium [10.46 pg/mL (2.91-99.36)] were lower than those of patients with hyperactive [30.97 pg/mL (10.66-88.21), p=0.03] and mixed delirium [50.18 pg/mL (17.22-66.55), p=0.02].

 

Conclusion: Our data suggest that delirium was associated with elevated blood levels of proinflammatory cytokine IL-6, but not with neuronal damage biomarkers S100B and NSE. We also found that delirium motor subtypes differed from each other with elevated IL-6 levels in hyperactive and mixed-type delirium.

 

You may cite this article as: Özkul A, Yılmaz A, Akyol A, et al. Biomarkers of neuronal damage and inflammation in delirium. Neurol Sci Neurophysiol 2019; 36(4): 193-7

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