• Users Online: 139
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2021  |  Volume : 38  |  Issue : 4  |  Page : 262-270

Protective effects of oxytocin and progesterone on paclitaxel-induced neuropathy in rats


1 Department of Veterinary Physiology, Faculty of Veterinary Medicine, Sivas Cumhuriyet University, Sivas, Turkey
2 Department of Veterinary Physiology, Faculty of Veterinary Medicine, Aydın Adnan Menderes University, Işıklı, Aydın, Turkey

Correspondence Address:
Mehmet Ekici
Department of Veterinary Physiology, Faculty of Veterinary Medicine, Sivas Cumhuriyet University, Sivas
Turkey
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/nsn.nsn_113_21

Rights and Permissions

Objective: Paclitaxel (Ptx), used to treat cancer, still causes neuropathic pain and peripheral neuropathy today. This study was conducted to evaluate the effects of progesterone (Pg) and oxytocin (Oxy) on peripheral neuropathy rat model induced by Ptx. Materials and Methods: A total of 38 male Sprague–Dawley rats were randomly divided into five groups, e.g., control (n = 6), Ptx (n = 8), Ptx + Oxy (n = 8), Ptx + Pg (n = 8), and Ptx + Oxy + Pg (n = 8). The rats were monitored daily for body weight change throughout the experiment. To evaluate peripheral neuropathy, electroneuromyography measurements (latency, amplitude, and motor nerve conduction velocity (MNCV)) were recorded from the sciatic nerve innervating the gastrocnemius muscle. Sciatic nerve tissue samples were collected for histopathological evaluation. Results: Ptx led to significant reductions in body weight from day 6 (P < 0.05). There was no difference between groups in the distal latency and amplitudes (P > 0.05). Proximal latency was prolonged in Ptx group rats than in other groups (P < 0.05). Importantly, it was found that MNCV was higher in the Ptx + Pg group than Ptx, Ptx + Oxy, and Ptx + Oxy + Pg groups (P < 0.05). Furthermore, Pg-administered rats had the lowest nerve degeneration compared to rats administered Oxy and Oxy + Pg (P < 0.05). Conclusions: The present findings suggest that Pg has a protective effect on peripheral neuropathy induced by Ptx in rat.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed132    
    Printed0    
    Emailed0    
    PDF Downloaded29    
    Comments [Add]    

Recommend this journal