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Year : 2020  |  Volume : 37  |  Issue : 4  |  Page : 208-214

Management of hardware infections in deep-brain stimulation: A 4-year, single-center experience

1 Department of Neurosurgery, Faculty of Medicine, Mersin University, Mersin, Turkey
2 Department of Neurology, Faculty of Medicine, Mersin University, Mersin, Turkey
3 Department of Neurosurgery, Neuro Spinal Hospital, Dubai, United Arab Emirates

Correspondence Address:
Vural Hamzaoglu
Department of Neurosurgery, Faculty of Medicine, Mersin University, Ciftlikkoy Campus, 33343, Yenisehir Mersin
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/NSN.NSN_43_20

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Objectives: The introduction of deep-brain stimulation (DBS) was a milestone in the treatment of movement disorders, intractable epilepsy, and severe psychiatric disorders. We aimed to identify risk factors for hardware infection in patients with these conditions who underwent DBS at our center over a 4-year period. Materials and Methods: Bilateral DBS was performed in seventy patients by the Department of Neurosurgery at the Mersin University School of Medicine between April 2016 and January 2020. The surgical indication was Parkinson's disease in 48 patients, dystonia in 11 patients (10 primary generalized and 1 secondary), and tremor in 11 patients (10 essential tremor and 1 other). Results: Infection was detected in eight patients (11.4%). There were no hardware complications other than infection or postoperative intracerebral hematomas. The entire device was explanted in four (50%) patients with infection; device explantation occurred at 3, 13, 19, and 42 months after surgery. The other 4 (50%) patients who developed infection were successfully treated with antibiotics without complication. A patient with primary dystonia who underwent bilateral globus pallidus interna DBS sustained a severe acute subdural hematoma due to trauma 45 days after electrode implantation but prior to stimulation. We elected not to explant the device after hematoma evacuation; delayed stimulation programming was successful. Conclusion: DBS surgeries are susceptible to complications related to the anatomic target, hardware, and the procedure itself. Infection is the most common complication; however, there is no established protocol for its treatment. Antibiotics and partial removal of the device may be a rational approach.

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