| ORIGINAL ARTICLE |
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| Year : 2020 | Volume
: 37
| Issue : 3 | Page : 141-147 |
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The close relation of tic disorders with childhood migraine and atopic background of both children and mothers
Gülen Guler Aksu1, Meryem Özlem Kütük2, Ali Evren Tufan3, Fevziye Toros1, Derya Uludüz4, Aynur Özge5
1 Department of Child and Adolescent Psychiatry, Mersin University School of Medicine, Mersin, Turkey
2 Department of Child and Adolescent Psychiatry, Başkent University School of Medicine, Adana, Turkey
3 Department of Child and Adolescent Psychiatry, Acibadem Mehmet Ali Aydinlar University School of Medicine, İstanbul, Turkey
4 Department of Neurology, Istanbul University Cerrahpaşa School of Medicine, İstanbul, Turkey
5 Department of Neurology, Mersin University School of Medicine, Mersin, Turkey
Correspondence Address:
Gülen Guler Aksu
Department of Child and Adolescent Psychiatry, Mersin University School of Medicine, Ciftlikkoy Campus, 33343, Mersin
Turkey
 Source of Support: None, Conflict of Interest: None
DOI: 10.4103/NSN.NSN_6_20
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Objective: This study aimed to evaluate primary headache disorders and other causative comorbidities (e.g., epilepsy, atopic disorders, recurrent abdominal pain, motion sickness, and headache) in children with tic disorders (TDs) and their mothers. Materials and Methods: In a multi-center, cross-sectional, familial association study using case–control design, youth (between 7 and 17 years) with TDs (TD, as per Diagnostic and Statistical Manual of Mental Disorders-5 criteria) and age- and sex-matched healthy controls and their mothers were evaluated in the aspect of functional syndromes spectrum including migraine, epilepsy, atopic disorders, motion sickness, and recurrent abdominal pain. Results: Seventy-nine youth with TD and 101 controls were included. Causative comorbidities, other than epilepsy and motion sickness were more common in children with TD with an odds ratio (OR) of 2.1 (atopy) and 3.9 (food allergy). Specifically, recurrent abdominal pain and migraine were found in 36.7% and 31.7% of children (vs. 18.8% and 16.8% of controls, ORs 2.5 and 2.3, respectively). Mothers of youth with TDs also have higher rates of atopy, drug allergy and allergic dermatitis (ORs; 3.8, 3.2 and 2.1; respectively). Conclusion: Results of recent studies suggest a possible link between atopic disorders, migraine, recurrent abdominal pain and TDs. Our results contribute to those studies and suggest that this relationship may extend to the mothers of children as well.
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